Extracellular lactate as an alternative energy source for retinal bipolar cells.

ABSTRACT: Retinal bipolar and amacrine cells receive visual information from photoreceptors and participate in the first steps of image processing in the retina. Several studies have suggested the operation of aerobic glycolysis and a lactate shuttle system in the retina due to the high production of this metabolite under aerobic conditions. However, whether bipolar cells form part of this metabolic circuit remains unclear. Here, we show that the monocarboxylate transporter 2 is expressed and functional in inner retinal neurons. Additionally, we used genetically encoded FRET nanosensors to demonstrate the ability of inner retinal neurons to consume extracellular lactate as an alternative to glucose. In rod bipolar cells, lactate consumption allowed cells to maintain the homeostasis of ions and elect

SUBMITTER: Calbiague-Garcia V 

PROVIDER: S-EPMC10966802 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature