Biogenesis, germination, and pathogenesis of Cryptococcus spores.

ABSTRACT: SUMMARYSpores are primary infectious propagules for the majority of human fungal pathogens; however, relatively little is known about their fundamental biology. One strategy to address this deficiency has been to develop the basidiospores of Cryptococcus into a model for pathogenic spore biology. Here, we provide an update on the state of the field with a comprehensive review of the data generated from the study of Cryptococcus basidiospores from their formation (sporulation) and differentiation (germination) to their roles in pathogenesis. Importantly, we provide support for the presence of basidiospores in nature, define the key characteristics that distinguish basidiospores from yeast cells, and clarify their likely roles as infectious particles. This review is intended to

SUBMITTER: Ortiz SC 

PROVIDER: S-EPMC10966950 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature