Associations between birth defects and childhood and adolescent germ cell tumors according to sex, histologic subtype, and site.

ABSTRACT:

Background

Studies have reported increased rates of birth defects among children with germ cell tumors (GCTs). However, few studies have evaluated associations by sex, type of defect, or tumor characteristics.

Methods

Birth defect-GCT associations were evaluated among pediatric patients (N = 552) with GCTs enrolled in the Germ Cell Tumor Epidemiology Study and population-based controls (N = 6380) without cancer from the Genetic Overlap Between Anomalies and Cancer in Kids Study. The odds ratio (OR) and 95% confidence interval (CI) of GCTs according to birth defects status were estimated by using unconditional logistic regression. All defects were considered collectively and by genetic and chromosomal syndromes and nonsyndromic defects. Stratification was by sex, tumor histol

SUBMITTER: Schraw JM 

PROVIDER: S-EPMC10967011 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature