The distribution of hrHPV genotypes among cervical cancer cases diagnosed across Ghana: a cross-sectional study.

ABSTRACT:

Background

The burden of cervical cancer in Ghana is high due to a lack of a national screening and vaccination program. Geographical variations in high-risk Human Papilloma Virus incidence and type should be considered for vaccine improvement and screening in LMICs.

Methods

A descriptive, multi-center cross-sectional study with purposive sampling of cases with cervical cancer diagnosed from January 2012 through to December 2018 was employed relying on archived Formalin Fixed Paraffin Embedded (FFPE) tissues from four (4) Teaching Hospitals. Cervical cancers were assessed for histopathological features following WHO guidelines. In addition, the novel Tumour Budding and Nest Size Grade (TBNS) for SCC, SILVA pattern of invasion for EAC and Tumour Infiltrating Lymphocytes (TILs

SUBMITTER: Akakpo PK 

PROVIDER: S-EPMC10967043 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature