Bioinformatics integration reveals key genes associated with mitophagy in myocardial ischemia-reperfusion injury.

ABSTRACT:

Background

Myocardial ischemia is a prevalent cardiovascular disorder associated with significant morbidity and mortality. While prompt restoration of blood flow is essential for improving patient outcomes, the subsequent reperfusion process can result in myocardial ischemia-reperfusion injury (MIRI). Mitophagy, a specialized autophagic mechanism, has consistently been implicated in various cardiovascular disorders. However, the specific connection between ischemia-reperfusion and mitophagy remains elusive. This study aims to elucidate and validate central mitophagy-related genes associated with MIRI through comprehensive bioinformatics analysis.

Methods

We acquired the microarray expression profile dataset (GSE108940) from the Gene Expression Omnibus (GEO) and identified di

SUBMITTER: Chen Z 

PROVIDER: S-EPMC10967080 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature