The association of urinary heavy metal exposure with frailty susceptibility and mortality in middle-aged and older adults: a population-based study.

ABSTRACT: Heavy metals' presence as environmental pollutants has a close link to adverse health effects. Frailty, a clinical syndrome hallmarked by elevated vulnerability to stressors, presents a substantial challenge in healthcare. However, the association between exposure to heavy metals and frailty largely remains unexplored. Utilizing data from the National Health and Nutrition Examination Survey (NHANES) spanning 2003-2018 and correlated with the U.S. National Death Index (NDI) from 2019, we investigated mortality outcomes. Logistic regression, Cox regression, Kaplan-Meier survival curves, weighted quantile-sum (WQS) regression, and Bayesian kernel machine regression (BKMR) were employed to assess the association between heavy metal exposure and frailty incidence and mortality in the frail popu

SUBMITTER: Zheng Z 

PROVIDER: S-EPMC10967095 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature