Upregulation of CIRP by its agonist prevents the development of heart failure in myocardial infarction rats.

ABSTRACT:

Background

Downregulated expression of cold-inducible RNA binding protein (CIRP), a stress-response protein, has been demonstrated in the hearts of patients with heart failure (HF). However, whether CIRP plays a critical role in the pathogenesis of HF remains unknown. Zr17-2 is a recently identified CIRP agonist, which can enhance the expression of CIRP in hearts. Herein, we evaluated the effects of zr17-2 on the development of HF in a rat model of myocardial infarction (MI).

Methods

Male SD rats were pretreated with CIRP agonist zr17-2 or vehicle saline for 6 consecutive days, followed by MI induction. 1-week post-MI, cardiac function, and structural and molecular changes were determined by echocardiography and molecular biology methods.

Results

Excitingly, we found

SUBMITTER: Zhang J 

PROVIDER: S-EPMC10967100 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature