Comprehensive analysis of the prognostic value and immunological role of IDO1 gene in pan-cancer.

ABSTRACT:

Objective

It has been demonstrated that IDO1, a target of immune checkpoint inhibition, functions as an oncogene in the majority of human malignancies. IDO1's function in human pan-cancers hasn't been thoroughly studied, though.

Materials and methods

The Kaplan-Meier (K-M) and COX analyses were applied to the survival analysis. Furthermore, we used Spearman's correlation analysis to examine the associations between IDO1 and microsatellite instability (MSI), DNA methyltransferases (DNMTs), tumor mutational burden (TMB), the associated genes of mismatch repair (MMR), and immune checkpoint biomarkers. Moreover, immunohistochemical analysis and qRT-PCR were used to evaluate IDO1's expression in pan-cancer cells.

Results

The findings of this study reveal that IDO1 has abno

SUBMITTER: Lin K 

PROVIDER: S-EPMC10967207 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature