The shifting lipidomic landscape of blood monocytes and neutrophils during pneumonia.

ABSTRACT: The lipidome of immune cells during infection has remained unexplored, although evidence of the importance of lipids in the context of immunity is mounting. In this study, we performed untargeted lipidomic analysis of blood monocytes and neutrophils from patients hospitalized for pneumonia and age- and sex-matched noninfectious control volunteers. We annotated 521 and 706 lipids in monocytes and neutrophils, respectively, which were normalized to an extensive set of internal standards per lipid class. The cellular lipidomes were profoundly altered in patients, with both common and distinct changes between the cell types. Changes involved every level of the cellular lipidome: differential lipid species, class-wide shifts, and altered saturation patterns. Overall, differential lipids were ma

SUBMITTER: Schuurman AR 

PROVIDER: S-EPMC10967382 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature