Tertiary lymphoid structures sustain cutaneous B cell activity in hidradenitis suppurativa.

ABSTRACT: Hidradenitis suppurativa (HS) is a chronic skin condition affecting approximately 1% of the US population. HS skin lesions are highly inflammatory and characterized by a large immune infiltrate. While B cells and plasma cells comprise a major component of this immune milieu, the biology and the contribution of these cells in HS pathogenesis are unclear. We aimed to investigate the dynamics and microenvironmental interactions of B cells within cutaneous HS lesions. Combining histological analysis, single-cell RNA sequencing, and spatial transcriptomics profiling of HS lesions, we defined the tissue microenvironment relative to B cell activity within this disease. Our findings identified tertiary lymphoid structures (TLSs) within HS lesions and described organized interactions among T cells,

SUBMITTER: Lowe MM 

PROVIDER: S-EPMC10967391 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature