Ontology highlight
ABSTRACT:
SUBMITTER: Johnson JL
PROVIDER: S-EPMC10967393 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
Johnson John L JL Sargsyan Davit D Neiman Eric M EM Hart Amy A Stojmirovic Aleksandar A Kosoy Roman R Irizar Haritz H Suárez-Fariñas Mayte M Song Won-Min WM Argmann Carmen C Avey Stefan S Shmuel-Galia Liraz L Vierbuchen Tim T Bongers Gerold G Sun Yu Y Edelstein Leonard L Perrigoue Jacqueline J Towne Jennifer E JE Hall Aisling O'Hara AO Fitzgerald Katherine A KA Hoebe Kasper K
JCI insight 20240208 3
The role of long noncoding RNAs (lncRNAs) in disease is incompletely understood, but their regulation of inflammation is increasingly appreciated. We addressed the extent of lncRNA involvement in inflammatory bowel disease (IBD) using biopsy-derived RNA-sequencing data from a large cohort of deeply phenotyped patients with IBD. Weighted gene correlation network analysis revealed gene modules of lncRNAs coexpressed with protein-coding genes enriched for biological pathways, correlated with epithe ...[more]