Identification and Functional Validation of Two Novel Antioxidant Peptides in Saffron.

ABSTRACT: Saffron (Crocus sativus L.) is one of the most expensive spices in the world, boasting rich medicinal and edible value. However, the effective development of active natural substances in saffron is still limited. Currently, there is a lack of comprehensive studies on the saffron stigma protein, and the main effect peptides have not been identified. In this study, the total protein composition of saffron stigmas was analyzed, and two main antioxidant peptides (DGGSDYLGK and VDPYFNK) were identified, which showed high antioxidant activity. Then, the stability of two peptides was further evaluated. Furthermore, our results suggested that these two peptides may protect HepG2 cells from H₂O₂-induced oxidative damage by significantly improving the activity of endogen

SUBMITTER: Long Y 

PROVIDER: S-EPMC10967730 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature