Immunologic Aspects in Fibrodysplasia Ossificans Progressiva.

ABSTRACT:

Background

Inflammation is a major driver of heterotopic ossification (HO), a condition of abnormal bone growth in a site that is not normally mineralized.

Purpose of review

This review will examine recent findings on the roles of inflammation and the immune system in fibrodysplasia ossificans progressiva (FOP). FOP is a genetic condition of aggressive and progressive HO formation. We also examine how inflammation may be a valuable target for the treatment of HO. Rationale/Recent findings: Multiple lines of evidence indicate a key role for the immune system in driving FOP pathogenesis. Critical cell types include macrophages, mast cells, and adaptive immune cells, working through hypoxia signaling pathways, stem cell differentiation signaling pathways, vascular regulatory pa

SUBMITTER: Diolintzi A 

PROVIDER: S-EPMC10967946 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature