Red Blood Cell Adenylate Energetics Is Related to Endothelial and Microvascular Function in Long COVID.

ABSTRACT: Adenine nucleotides play a critical role in maintaining essential functions of red blood cells (RBCs), including energy metabolism, redox status, shape fluctuations and RBC-dependent endothelial and microvascular functions. Recently, it has been shown that infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) might lead to morphological and metabolic alterations in erythrocytes in both mild and severe cases of coronavirus disease (COVID-19). However, little is known about the effects of COVID-19 on the nucleotide energetics of RBCs nor about the potential contribution of nucleotide metabolism to the long COVID syndrome. This study aimed to analyze the levels of adenine nucleotides in RBCs isolated from patients 12 weeks after mild SARS-CoV-2 infection who suffered

SUBMITTER: Romanowska-Kocejko M 

PROVIDER: S-EPMC10968064 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature