Dataset Information

Highly Sensitive and Wide-Range Detection of Thiabendazole via Surface-Enhanced Raman Scattering Using Bimetallic Nanoparticle-Functionalized Nanopillars.

ABSTRACT: Thiabendazole (TBZ) is a benzimidazole; owing to its potent antimicrobial properties, TBZ is extensively employed in agriculture as a fungicide and pesticide. However, TBZ poses environmental risks, and excessive exposure to TBZ through various leakage pathways can cause adverse effects in humans. Therefore, a method must be developed for early and sensitive detection of TBZ over a range of concentrations, considering both human and environmental perspectives. In this study, we used silver nanopillar structures (SNPis) and Au@Ag bimetallic nanoparticles (BNPs) to fabricate a BNP@SNPi substrate. This substrate exhibited a broad reaction surface with significantly enhanced surface-enhanced Raman scattering hotspots, demonstrating excellent Raman performance, along with high reproducibility, sensitivity, and selectivity for TBZ detection. Ultimately, the BNP@SNPi substrate successfully detected TBZ across a wide concentration range in samples of tap water, drinking water, juice, and human serum, with respective limits of detection of 146.5, 245.5, 195.6, and 219.4 pM. This study highlights BNP@SNPi as a promising sensor platform for TBZ detection in diverse environments and contributes to environmental monitoring and bioanalytical studies.

SUBMITTER: Park H

PROVIDER: S-EPMC10968244 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature

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Publications

Highly Sensitive and Wide-Range Detection of Thiabendazole via Surface-Enhanced Raman Scattering Using Bimetallic Nanoparticle-Functionalized Nanopillars.

Park Hyunjun H Kim Gayoung G Kim Woochang W Park Eugene E Park Joohyung J Park Jinsung J

Biosensors 20240304 3

Thiabendazole (TBZ) is a benzimidazole; owing to its potent antimicrobial properties, TBZ is extensively employed in agriculture as a fungicide and pesticide. However, TBZ poses environmental risks, and excessive exposure to TBZ through various leakage pathways can cause adverse effects in humans. Therefore, a method must be developed for early and sensitive detection of TBZ over a range of concentrations, considering both human and environmental perspectives. In this study, we used silver nanop ...[more]

PMID: 38534240

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Project description:Pesticides pose a great threat to human health and their rapid detection has become an urgent public safety issue engaging the scientific community to search for fast and reliable detection techniques. In this context, Surface Enhanced Raman Spectroscopy (SERS) has emerged as a valuable detection and analysis tool due to its high sensitivity and selectivity, proving its suitability for the food industry and environmental monitoring applications. Here, we report on the fabrication of colloidal silver nanoparticle (AgNP) films by convective self-assembly (CSA) on solid planar substrate and their use for the SERS analyses of two types of pesticides, the fungicide thiabendazole (TBZ) and the insecticide α-endosulfan (α-ES). Electron microscopy shows that these nanoparticle films are dense, highly compact, and uniform across several mm2 areas. The SERS efficiency of the fabricated AgNP films is evaluated using a well-known Raman probe, p-aminothiophenol, for multiple excitation laser lines (532 nm, 633 nm, and 785 nm). The films exhibit the largest SERS enhancement factors for 785 nm excitation, reaching values larger than 105. Thiabendazole could be readily adsorbed on the AgNPs without any sample surface functionalization and detected down to 10-6 M, reaching the sub-ppm range. Endosulfan, a challenging analyte with poor affinity to metal surfaces, was captured near the metal surface by using self-assembled alkane thiol monolayers (hexanethiol and octanethiol), as demonstrated by the thorough vibrational band analysis, and supported by density functional theory (DFT) calculations. In addition, principal component analysis (PCA) based on SERS spectra offers significant leverage in discrimination of the molecules anchored onto the metallic nanostructured surface. This present study demonstrates the utility of self-assembled colloidal nanoparticle films as SERS substrates for a broad range of analytes (para-aminothiophenol, thiabendazole, α-endosulfan, and alkanethiols) and contributes to the development of SERS-based sensors for pesticides detection, identification and monitoring.

Dataset Information

Highly Sensitive and Wide-Range Detection of Thiabendazole via Surface-Enhanced Raman Scattering Using Bimetallic Nanoparticle-Functionalized Nanopillars.

Publications

Highly Sensitive and Wide-Range Detection of Thiabendazole via Surface-Enhanced Raman Scattering Using Bimetallic Nanoparticle-Functionalized Nanopillars.

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