The "Bad Father": Paternal Role in Biology of Pregnancy and in Birth Outcome.

ABSTRACT: Pregnancy is generally studied as a biological interaction between a mother and a fetus; however, the father, with his characteristics, lifestyle, genetics, and living environment, is by no means unrelated to the outcome of pregnancy. The half of the fetal genetic heritage of paternal derivation can be decisive in cases of inherited chromosomal disorders, and can be the result of de novo genetic alterations. In addition to the strictly pathological aspects, paternal genetics may transmit thrombophilic traits that affect the implantation and vascular construction of the feto-placental unit, lead to placenta-mediated diseases such as pre-eclampsia and fetal growth retardation, and contribute to the multifactorial genesis of preterm delivery. Biological aspects of immunological tolerance to p

SUBMITTER: Giannubilo SR 

PROVIDER: S-EPMC10968330 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature