LL-37: Structures, Antimicrobial Activity, and Influence on Amyloid-Related Diseases.

ABSTRACT: Antimicrobial peptides (AMPs), as well as host defense peptides (HDPs), constitute the first line of defense as part of the innate immune system. Humans are known to express antimicrobial precursor proteins, which are further processed to generate AMPs, including several types of α/β defensins, histatins, and cathelicidin-derived AMPs like LL37. The broad-spectrum activity of AMPs is crucial to defend against infections caused by pathogenic bacteria, viruses, fungi, and parasites. The emergence of multi-drug resistant pathogenic bacteria is of global concern for public health. The prospects of targeting antibiotic-resistant strains of bacteria with AMPs are of high significance for developing new generations of antimicrobial agents. The 37-residue long LL37, the only cathelicidin family of

SUBMITTER: Bhattacharjya S 

PROVIDER: S-EPMC10968335 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature