PTCH1 Gene Variants, mRNA Expression, and Bioinformatics Insights in Mexican Cutaneous Squamous Cell Carcinoma Patients.

ABSTRACT:

Background

Skin cancer is one of the most frequent types of cancer, and cutaneous squamous cell carcinoma (cSCC) constitutes 20% of non-melanoma skin cancer (NMSC) cases. PTCH1, a tumor suppressor gene involved in the Sonic hedgehog signaling pathway, plays a crucial role in neoplastic processes.

Methods

An analytical cross-sectional study, encompassing 211 cSCC patients and 290 individuals in a control group (CG), was performed. A subgroup of samples was considered for the relative expression analysis, and the results were obtained using quantitative real-time PCR (qPCR) with TaqMan^® probes. The functional, splicing, and disease-causing effects of the proposed variants were explored via bioinformatics.

Results

cSCC was predominant in men, especially

SUBMITTER: Zambrano-Roman M 

PROVIDER: S-EPMC10968426 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature