Neuroprotective Effects of Krypton Inhalation on Photothrombotic Ischemic Stroke.

ABSTRACT: This is the first in vivo study to investigate the neuroprotective effects of krypton on focal cerebral ischemia. The aim of the study was to analyze the effect of 2 h of inhalation of a krypton-oxygen mixture (Kr 70%/O₂ 30%) on the recovery of neurological functions and the degree of brain damage in rats after photoinduced ischemic stroke (PIS) and to investigate the possible mechanisms responsible for this neuroprotection. Experiments were performed on male Wistar rats weighing 250-300 g (n = 32). Animals were randomized into four groups. Two groups (n = 20) underwent photoinduced ischemic stroke, followed by 2 h of inhalation of krypton-oxygen mixture consisting of Kr 70%/O₂ 30% or a nitrogen-oxygen breathing mixture consisting of N₂ 70%/O₂ 30

SUBMITTER: Antonova VV 

PROVIDER: S-EPMC10968517 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature