Nephrotic Syndrome: From Pathophysiology to Novel Therapeutic Approaches.

ABSTRACT: Nephrotic edema stands out as one of the most common complications of nephrotic syndrome. The effective management of hypervolemia is paramount in addressing this condition. Initially, "the underfill hypothesis" suggested that proteinuria and hypoalbuminemia led to fluid extravasation into the interstitial space, causing the intravascular hypovolemia and activation of neurohormonal compensatory mechanisms, which increased the retention of salt and water. Consequently, the recommended management involved diuretics and human-albumin infusion. However, recent findings from human and animal studies have unveiled a kidney-limited sodium-reabsorption mechanism, attributed to the presence of various serine proteases in the tubular lumen-activating ENaC channels, thereby causing sodium reabsorptio

SUBMITTER: Fratila VG 

PROVIDER: S-EPMC10968602 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature