A novel classification predicts prognosis and drug sensitivity in osteosarcoma based on alterations in gene sets.
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ABSTRACT:
SUBMITTER: Ye S
PROVIDER: S-EPMC10968677 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
Publications
A novel classification predicts prognosis and drug sensitivity in osteosarcoma based on alterations in gene sets.
Ye Shuxi S Wang Xiaopeng X Chen Rongchun R
Aging 20240228 5
Osteosarcoma is a cancer originating in the bone cells, specifically in the osteoblasts. Previous studies mainly focused on particular molecules but the whole pathway network. We comprehensively analyzed the enrichment score of each signal pathway and identified a novel classification by 20 machine learning algorithms. Furthermore, differences in tumor immune infiltration cells and drug sensitivity were compared in low and high groups. We identified a model consisting of four signaling pathways ...[more]
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