A Mendelian randomization analysis identifies causal association between sarcopenia and gastroesophageal reflux disease.

ABSTRACT: The incidence of gastroesophageal reflux disease (GERD) is increasing with the advancement of world population aging, affecting the population health worldwide. Recently, there were several researches to suggest the association between GERD and sarcopenia, but evidence supporting the causal effect was absent. The purpose of this study is to determine the causal relationship between GERD and sarcopenia through a Mendelian randomization (MR) study. We conducted an MR analysis by using summary-level data of genome-wide association studies (GWASs) in the European population. The inverse variance weighted (IVW) method was used as the primary analytical method for evaluating causality. In addition, four other MR methods were performed to supplement the IVW results. We also used the Mendelian ran

SUBMITTER: Hu R 

PROVIDER: S-EPMC10968686 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature