SUMF1 overexpression promotes tumorous cell growth and migration and is correlated with the immune status of patients with glioma.

ABSTRACT:

Background

Glioma is a prevalent type of malignant tumor. To date, there is a lack of literature reports that have examined the association between sulfatase modifying factor 1 (SUMF1) and glioma.

Methods

The levels of SUMF1 were examined, and their relationships with the diagnosis, prognosis, and immune microenvironment of patients with glioma were investigated. Cox and Lasso regression analysis were employed to construct nomograms and risk models associated with SUMF1. The functions and mechanisms of SUMF1 were explored and verified using gene ontology, cell counting kit-8, wound healing, western blotting, and transwell experiments.

Results

SUMF1 expression tended to increase in glioma tissues. SUMF1 overexpression was linked to the diagnosis of cancer, survival eve

SUBMITTER: Zhang P 

PROVIDER: S-EPMC10968700 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature