Genome-wide transcriptome profiling and development of age prediction models in the human brain.

ABSTRACT: Aging-related transcriptome changes in various regions of the healthy human brain have been explored in previous works, however, a study to develop prediction models for age based on the expression levels of specific panels of transcripts is lacking. Moreover, studies that have assessed sexually dimorphic gene activities in the aging brain have reported discrepant results, suggesting that additional studies would be advantageous. The prefrontal cortex (PFC) region was previously shown to have a particularly large number of significant transcriptome alterations during healthy aging in a study that compared different regions in the human brain. We harmonized neuropathologically normal PFC transcriptome datasets obtained from the Gene Expression Omnibus (GEO) repository, ranging in age from 2

SUBMITTER: Zarrella JA 

PROVIDER: S-EPMC10968712 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature