Intraoperative Techniques That Define the Mucosal Margins of Oral Cancer In-Vivo: A Systematic Review.

ABSTRACT:

Background

This systematic review investigates techniques for determining adequate mucosal margins during the resection of oral squamous cell carcinoma (SCC). The primary treatment involves surgical removal with ≥5 mm margins, highlighting the importance of accurate differentiation between SCC and dysplasia during surgery.

Methods

A comprehensive Embase and PubMed literature search was performed. Studies underwent quality assessment using QUADAS-2.

Results

After the full-text screening and exclusion of studies exhibiting high bias, eight studies were included, focusing on three margin visualization techniques: autofluorescence, iodine staining, and narrow-band imaging (NBI). Negative predictive value (NPV) was calculable across the studies, though reference standards

SUBMITTER: de Koning KJ 

PROVIDER: S-EPMC10968727 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature