A-Z of Epigenetic Readers: Targeting Alternative Splicing and Histone Modification Variants in Cancer.

ABSTRACT: Epigenetic 'reader' proteins, which have evolved to interact with specific chromatin modifications, play pivotal roles in gene regulation. There is growing interest in the alternative splicing mechanisms that affect the functionality of such epigenetic readers in cancer etiology. The current review considers how deregulation of epigenetic processes and alternative splicing events contribute to pathophysiology. An A-Z guide of epigenetic readers is provided, delineating the antagonistic 'yin-yang' roles of full-length versus spliced isoforms, where this is known from the literature. The examples discussed underscore the key contributions of epigenetic readers in transcriptional regulation, early development, and cancer. Clinical implications are considered, offering insights into precision

SUBMITTER: Mohan N 

PROVIDER: S-EPMC10968829 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature