Gene Expression of GABA_A Receptor Subunits and Association with Patient Survival in Glioma.

ABSTRACT: Rapid neuronal inhibition in the brain is mediated by γ-aminobutyric acid (GABA) activation of GABA_A receptors. The GABRA5 gene, which encodes the α5 subunit of the GABA_A receptor, has been implicated in an aggressive subgroup of medulloblastoma (MB), a type of pediatric brain tumor. However, the possible role of GABA_A receptor subunits in glioma remains poorly understood. Here, we examined the expression of genes encoding GABA_A receptor subunits in different types of glioma, and its possible association with patient prognosis assessed by overall survival (OS). Data were obtained from the French and The Cancer Genome Atlas Brain Lower Grade Glioma (TCGA-LGG) datasets and analyzed for expression of GABA_A receptor subunit genes. O

SUBMITTER: Badalotti R 

PROVIDER: S-EPMC10969028 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature