Pyridoxal 5'-Phosphate Biosynthesis by Pyridox-(am)-ine 5'-Phosphate Oxidase: Species-Specific Features.

ABSTRACT: Enzymes reliant on pyridoxal 5'-phosphate (PLP), the metabolically active form of vitamin B₆, hold significant importance in both biology and medicine. They facilitate various biochemical reactions, particularly in amino acid and neurotransmitter metabolisms. Vitamin B₆ is absorbed by organisms in its non-phosphorylated form and phosphorylated within cells via pyridoxal kinase (PLK) and pyridox-(am)-ine 5'-phosphate oxidase (PNPOx). The flavin mononucleotide-dependent PNPOx enzyme converts pyridoxine 5'-phosphate and pyridoxamine 5'-phosphate into PLP. PNPOx is vital for both biosynthesis and salvage pathways in organisms producing B₆ vitamers. However, for those depending on vitamin B₆ as a nutrient, PNPOx participates only in the salvage pathwa

SUBMITTER: Rivero M 

PROVIDER: S-EPMC10969823 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature