Super-Enhancers and Their Parts: From Prediction Efforts to Pathognomonic Status.

ABSTRACT: Super-enhancers (SEs) are regions of the genome that play a crucial regulatory role in gene expression by promoting large-scale transcriptional responses in various cell types and tissues. Recent research suggests that alterations in super-enhancer activity can contribute to the development and progression of various disorders. The aim of this research is to explore the multifaceted roles of super-enhancers in gene regulation and their significant implications for understanding and treating complex diseases. Here, we study and summarise the classification of super-enhancer constituents, their possible modes of interaction, and cross-regulation, including super-enhancer RNAs (seRNAs). We try to investigate the opportunity of SE dynamics prediction based on the hierarchy of enhancer single e

SUBMITTER: Vasileva AV 

PROVIDER: S-EPMC10969950 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature