Roles of Histone H2A Variants in Cancer Development, Prognosis, and Treatment.

ABSTRACT: Histones are nuclear proteins essential for packaging genomic DNA and epigenetic gene regulation. Paralogs that can substitute core histones (H2A, H2B, H3, and H4), named histone variants, are constitutively expressed in a replication-independent manner throughout the cell cycle. With specific chaperones, they can be incorporated to chromatin to modify nucleosome stability by modulating interactions with nucleosomal DNA. This allows the regulation of essential fundamental cellular processes for instance, DNA damage repair, chromosomal segregation, and transcriptional regulation. Among all the histone families, histone H2A family has the largest number of histone variants reported to date. Each H2A variant has multiple functions apart from their primary role and some, even be further specia

SUBMITTER: Lai PM 

PROVIDER: S-EPMC10969971 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature