Microcurrent-Mediated Modulation of Myofibroblasts for Cardiac Repair and Regeneration.

ABSTRACT: Cardiovascular diseases are a significant cause of illness and death worldwide, often resulting in myofibroblast differentiation, pathological remodeling, and fibrosis, characterized by excessive extracellular matrix protein deposition. Treatment options for cardiac fibrosis that can effectively target myofibroblast activation and ECM deposition are limited, necessitating an unmet need for new therapeutic approaches. In recent years, microcurrent therapy has demonstrated promising therapeutic effects, showcasing its translational potential in cardiac care. This study therefore sought to investigate the effects of microcurrent therapy on cardiac myofibroblasts, aiming to unravel its potential as a treatment for cardiac fibrosis and heart failure. The experimental design involved the differe

SUBMITTER: Bachamanda Somesh D 

PROVIDER: S-EPMC10970173 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature