Sequence Alignment-Based Prediction of Myosin 7A: Structural Implications and Protein Interactions.

ABSTRACT: Myosin, a superfamily of motor proteins, obtain the energy they require for movement from ATP hydrolysis to perform various functions by binding to actin filaments. Extensive studies have clarified the diverse functions performed by the different isoforms of myosin. However, the unavailability of resolved structures has made it difficult to understand the way in which their mechanochemical cycle and structural diversity give rise to distinct functional properties. With this study, we seek to further our understanding of the structural organization of the myosin 7A motor domain by modeling the tertiary structure of myosin 7A based on its primary sequence. Multiple sequence alignment and a comparison of the models of different myosin isoforms and myosin 7A not only enabled us to identify hig

SUBMITTER: Yu CJ 

PROVIDER: S-EPMC10970253 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature