The Oxidative Stress Response Highly Depends on Glucose and Iron Availability in Aspergillus fumigatus.

ABSTRACT: Pathogens have to cope with oxidative, iron- and carbon(glucose)-limitation stresses in the human body. To understand how combined iron-carbon limitation alters oxidative stress responses, Aspergillus fumigatus was cultured in glucose-peptone or peptone containing media supplemented or not with deferiprone as an iron chelator. Changes in the transcriptome in these cultures were recorded after H₂O₂ treatment. Responses to oxidative stress were highly dependent on the availability of glucose and iron. Out of the 16 stress responsive antioxidative enzyme genes, only the cat2 catalase-peroxidase gene was upregulated in more than two culturing conditions. The transcriptional responses observed in iron metabolism also varied substantially in these cultures. On

SUBMITTER: Emri T 

PROVIDER: S-EPMC10970741 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature