Ontology highlight
ABSTRACT:
SUBMITTER: Alexander KC
PROVIDER: S-EPMC10970932 | biostudies-literature | 2024 Mar
REPOSITORIES: biostudies-literature
Alexander Kyle C KC Anderson Carlton W CW Agala Chris B CB Tasoudis Panagiotis P Collins Elizabeth N EN Ding Yiwen Y Blackwell John W JW Willcox Danielle E DE Farivar Behzad S BS Kibbe Melina R MR Ikonomidis John S JS Akerman Adam W AW
Journal of clinical medicine 20240308 6
<b>Background:</b> Thoracic aortic aneurysms (TAAs) associated with Marfan syndrome (MFS) are unique in that extracellular matrix metalloproteinase inducer (EMMPRIN) levels do not behave the way they do in other cardiovascular pathologies. EMMPRIN is shed into the circulation through the secretion of extracellular vesicles. This has been demonstrated to be dependent upon the Membrane Type-1 MMP (MT1-MMP). We investigated this relationship in MFS TAA tissue and plasma to discern why unique profil ...[more]