Exploring Mechanisms of Antifungal Lipopeptide Iturin A from Bacillus against Aspergillus niger.

ABSTRACT: The control of Aspergillus niger (A. niger) is of great significance for the agricultural economy and food safety. In this study, the antifungal effect and mechanism of iturin A from Bacillus amyloliquefaciens (CGMCC No. 8473) against A. niger (ATCC 16404) were investigated using biochemical analyses and proteomics. Changes in a mycelium treated with iturin A were observed using scanning electron microscopy and transmission electron microscopy, including mycelial twisting and collapse, organelle disintegration, and intracellular vacuolization. The cytomembrane integrity of A. niger was affected by iturin A, as detected by propidium iodide staining. In addition, the generation of excess reactive oxygen species, the hyperpolarization of the mitochondrial me

SUBMITTER: Wang S 

PROVIDER: S-EPMC10970988 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature