Human-Fungal Pathogen Interactions from the Perspective of Immunoproteomics Analyses.

ABSTRACT: Antibody immunity is now known to play a critical role in combating mycotic infections. The identification of molecules that can elicit an antibody response against fungal pathogens is the first step in developing antibody-based therapeutic strategies. Antigenic proteins are molecules recognized by the immune system that can stimulate antibody production and, therefore, can be a direct target for studying human-fungal pathogen interactions. Advances in recent immunoproteomic approaches have substantially aided in determining the key antigenic proteins on a large scale. In this review, we present a collection of antigenic proteins identified in yeast, dimorphic, and filamentous fungal pathogens to date. The general features of antigenic proteins are summarized and reveal that the proteins c

SUBMITTER: Wangsanut T 

PROVIDER: S-EPMC10971113 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature