Unusual and Unconsidered Mechanisms of Bacterial Resilience and Resistance to Quinolones.

ABSTRACT: Quinolone resistance has been largely related to the presence of specific point mutations in chromosomal targets, with an accessory role of impaired uptake and enhanced pump-out. Meanwhile the relevance of transferable mechanisms of resistance able to protect the target of pump-out or inactivate quinolones has been increasingly reported since 1998. Nevertheless, bacteria have other strategies and mechanisms allowing them to survive and even proliferate in the presence of quinolones, which might be qualified as resistance or resilience mechanisms. These include decreasing levels of quinolone target production, transient amoeba protection, benthonic lifestyle, nutrient-independent slow growth, activation of stringent response, inactivation or degradation of quinolones as well as apparently u

SUBMITTER: Ruiz J 

PROVIDER: S-EPMC10971285 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature