Supplementation of Nicotinic Acid and Its Derivatives Up-Regulates Cellular NAD⁺ Level Rather than Nicotinamide Derivatives in Cultured Normal Human Epidermal Keratinocytes.

ABSTRACT: Nicotinamide adenine dinucleotide (NAD⁺) plays a pivotal role in various physiological processes within mammalian cells, including energy metabolism, redox homeostasis, and genetic regulation. In the majority of mammalian cellular contexts, NAD⁺ biosynthesis primarily relies on vitamin B3, including nicotinamide (NAM) and nicotinic acid (NA). The concept of NAD⁺ augmentation therapy has recently emerged as a promising strategy to mitigate aging-associated phenomena, termed rejuvenation. Despite the involvement of diverse enzymatic cascades in NAD⁺ biosynthesis, certain cellular environments exhibit deficiencies in specific enzymes, suggesting cell type-dependent variability in optimal NAD⁺ precursor selection. However, the optimization

SUBMITTER: Oyama T 

PROVIDER: S-EPMC10971338 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature