Shear Stress Quantification in Tissue Engineering Bioreactor Heart Valves: A Computational Approach.

ABSTRACT: Tissue-engineered heart valves can grow, repair, and remodel after implantation, presenting a more favorable long-term solution compared to mechanical and porcine valves. Achieving functional engineered valve tissue requires the maturation of human cells seeded onto valve scaffolds under favorable growth conditions in bioreactors. The mechanical stress and strain on developing valve tissue caused by different pressure and flow conditions in bioreactors are currently unknown. The aim of this study is to quantify the wall shear stress (WSS) magnitude in heart valve prostheses under different valve geometries and bioreactor flow rates. To achieve this, this study used fluid-structure interaction simulations to obtain the valve's opening geometries during the systolic phase. These geometries w

SUBMITTER: Dave R 

PROVIDER: S-EPMC10971346 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature