Genetic Factors Contributing to the Pathogenesis of Essential Hypertension in Two African Populations.

ABSTRACT: The African continent has the highest prevalence of hypertension globally, with South Africa reporting the highest prevalence in Southern Africa. While the influence of genetic variability in the pathogenesis of hypertension is well described internationally, limited reports are available for African populations. This study aimed to assess the association of genetic variants and essential hypertension in a cohort of two ethnic South African population groups. Two hundred and seventy-seven hypertensive and one hundred and seventy-six normotensive individuals were genotyped for 78 variants. Genotyping was performed using the Illumina GoldenGate Assay and allele-specific polymerase chain reaction. The association of variants was assessed using the Fisher Exact test under the additive and alle

SUBMITTER: Kalideen K 

PROVIDER: S-EPMC10971352 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature