Ontology highlight
ABSTRACT:
SUBMITTER: Valverde-Lopez JA
PROVIDER: S-EPMC10971546 | biostudies-literature | 2024 Mar
REPOSITORIES: biostudies-literature
Valverde-Lopez Jose A JA Li-Bao Lin L Sierra Rocío R Santos Elisa E Giovinazzo Giovanna G Díaz-Díaz Covadonga C Torres Miguel M
PLoS genetics 20240315 3
Cell Competition is a process by which neighboring cells compare their fitness. As a result, viable but suboptimal cells are selectively eliminated in the presence of fitter cells. In the early mammalian embryo, epiblast pluripotent cells undergo extensive Cell Competition, which prevents suboptimal cells from contributing to the newly forming organism. While competitive ability is regulated by MYC in the epiblast, the mechanisms that contribute to competitive fitness in this context are largely ...[more]