Therapeutic Targets in the Management of Dry Eye Disease Associated with Sjogren's Syndrome: An Updated Review of Current Insights and Future Perspectives.

ABSTRACT: Dry eye disease (DED) is a continuing medical challenge, further worsened in the autoimmune inflammatory hyperactivation milieu of Sjögren's syndrome (SS) due to disturbances to innate and adaptive immunity with malfunctioning neuro-endocrine control. However, the pathogenetic mechanisms of SS DED are not fully established. This review summarized the available evidence, from systematic reviews, meta-analyses, and randomized clinical trials, for the efficacy and safety of the available ocular therapeutics for the management of SS DED. Relevant studies were obtained from major databases using appropriate keywords. The available largely empirical symptomatic, supportive, and restorative treatments have significant limitations as they do not alter local and systemic disease progression. Topica

SUBMITTER: Almulhim A 

PROVIDER: S-EPMC10971622 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature