Chitosan as an Alternative to Oil-Based Materials for the Fabrication of Lab-on-a-Chip.

ABSTRACT: Given the growing importance of lab-on-a-chip in a number of fields, such as medical diagnosis or environmental analysis, the fact that the current fabrication process relies mainly on oil-based polymers raises an ecological concern. As an eco-responsible alternative, we presented, in this article, a manufacturing process for microfluidic devices from chitosan, a bio-sourced, biodegradable, and biocompatible polysaccharide. From chitosan powder, we produced thick and rigid films. To prevent their dissolution and reduce their swelling when in contact with aqueous solutions, we investigated a film neutralization step and characterized the mechanical and physical properties of the resulting films. On these neutralized chitosan films, we compared two micropatterning methods, i.e., hot embossin

SUBMITTER: Zimmer M 

PROVIDER: S-EPMC10971945 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature