Transcriptomic Profiling of Pleural Effusions: Differences in Malignant and Infectious Fluids.

ABSTRACT: Background and Objectives: Different cellular and molecular processes are involved in the production of malignant and infectious pleural effusions. However, the underlying mechanisms responsible for these differences or their consequences remain incompletely understood. The objective of this study was to identify differences in gene expression in pleural exudates of malignant and infectious aetiology and establish the possible different biological processes involved in both situations. Materials and Methods: RNA transcriptomic analysis was performed on 46 pleural fluid samples obtained during diagnostic thoracocenteses from 46 patients. There were 35 exudates (19 malignant and 16 infectious effusions) and 11 transudates that were used as a reference control group. Differentia

SUBMITTER: Zamora-Molina L 

PROVIDER: S-EPMC10971961 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature