Vitamin D Deficiency, Chronic Kidney Disease and Periodontitis.

ABSTRACT: Vitamin D has important anti-inflammatory, anti-microbial properties and plays a central role in the host immune response. Due to the crucial role of the kidneys in the metabolism of vitamin D, patients with chronic kidney disease (CKD) are prone to vitamin D deficiency. The resultant reduction in the production of calcitriol, the activated form of vitamin D, in patients with CKD is responsible for exacerbating the existing renal impairment and periodontal inflammation. Recent evidence suggests a bidirectional, causal relationship between periodontitis and renal functional status. Both conditions have shared pathophysiological mechanisms including oxidative stress, increases in the systemic inflammatory burden and impaired host response. This review explores the association between vitamin

SUBMITTER: Ganimusa I 

PROVIDER: S-EPMC10972110 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature