Immunogenetic Background of Chronic Lymphoproliferative Disorders in Romanian Patients-Case Control Study.

ABSTRACT:

Background and objectives

The implications of the genetic component in the initiation and development of chronic lymphoproliferative disorders have been the subject of intense research efforts. Some of the most important genes involved in the occurrence and evolution of these pathologies are the HLA genes. The aim of this study is to analyze, for the first time, possible associations between chronic lymphoproliferative diseases and certain HLA alleles in the Romanian population.

Materials and methods

This study included 38 patients with chronic lymphoproliferative disorders, diagnosed between 2021 and 2022 at Fundeni Clinical Institute, Bucharest, Romania, and 50 healthy controls. HLA class I and class II genes (HLA-A/B/C, HLA-DQB1/DPB1/DRB1) were investigated by doing high

SUBMITTER: Tizu M 

PROVIDER: S-EPMC10972167 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature