Molecular Subtypes, microRNAs and Immunotherapy Response in Metastatic Colorectal Cancer.

ABSTRACT: Currently, only a limited set of molecular traits are utilized to direct treatment for metastatic CRC (mCRC). The molecular classification of CRC depicts tumor heterogeneity based on gene expression patterns and aids in comprehending the biological characteristics of tumor formation, growth and prognosis. Additionally, it assists physicians in tailoring the therapeutic approach. Microsatellite instability (MSI-H)/deficient mismatch repair proteins (MMRd) status has become a ubiquitous biomarker in solid tumors, caused by mutations or methylation of genes and, in turn, the accumulation of mutations and antigens that subsequently induce an immune response. Immune checkpoint inhibitors (ICI) have recently received approval for the treatment of mCRC with MSI-H/MMRd status. However, certain ind

SUBMITTER: Gherman A 

PROVIDER: S-EPMC10972200 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature