In Silico Analysis of Novel Bacterial Metabolites with Anticancer Activities.

ABSTRACT: Resistance to anticancer therapeutics is a major global concern. Thus, new anticancer agents should be aimed against novel protein targets to effectively mitigate the increased resistance. This study evaluated the potential of secondary metabolites from a bacterial endophyte, as new anticancer agents, against a novel protein target, fibroblast growth factor. In silico genomic characterization of the Bacillus sp. strain MHSD_37 was used to identify potential genes involved in encoding secondary metabolites with biological activity. The strain was also exposed to stress and liquid chromatography-mass spectrometry used for the identification and annotation of secondary metabolites of oligopeptide class with anticancer activity. Selected metabolites were evaluated for their anticancer a

SUBMITTER: Maumela P 

PROVIDER: S-EPMC10972250 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature