Assessment of the Nonlinear Electrophoretic Migration of Nanoparticles and Bacteriophages.

ABSTRACT: Bacteriophage therapy presents a promising avenue for combating antibiotic-resistant bacterial infections. Yet, challenges exist, particularly, the lack of a straightforward purification pipeline suitable for widespread application to many phage types, as some phages are known to undergo significant titer loss when purified via current techniques. Electrokinetic methods offer a potential solution to this hurdle, with nonlinear electrophoresis emerging as a particularly appealing approach due to its ability to discern both the size and shape of the target phage particles. Presented herein is the electrokinetic characterization of the mobility of nonlinear electrophoresis for two phages (SPN3US and ϕKZ) and three types of polystyrene nanoparticles. The latter served as controls and were sele

SUBMITTER: Lomeli-Martin A 

PROVIDER: S-EPMC10972334 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature