AXL inhibition suppresses early allograft monocyte-to-macrophage differentiation and prolongs allograft survival.

ABSTRACT: Innate immune cells are important in the initiation and potentiation of alloimmunity in transplantation. Immediately upon organ anastomosis and reperfusion, recipient monocytes enter the graft from circulation and differentiate to inflammatory macrophages to promote allograft inflammation. However, factors that drive their differentiation to inflammatory macrophages are not understood. Here, we show that the receptor tyrosine kinase AXL was a key driver of early intragraft differentiation of recipient infiltrating monocytes to inflammatory macrophages in the presence of allogeneic stimulation and cell-to-cell contact. In this context, the differentiated inflammatory macrophages were capable of efficient alloantigen presentation and allostimulation of T cells of the indirect pathway. Conseq

SUBMITTER: Jordan CZ 

PROVIDER: S-EPMC10972596 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature